{"id":857,"date":"2013-08-03T08:32:30","date_gmt":"2013-08-03T11:32:30","guid":{"rendered":"http:\/\/www.robertofrancodoamaral.com.br\/blog\/?p=857"},"modified":"2024-06-24T19:05:32","modified_gmt":"2024-06-24T22:05:32","slug":"pqq-pirroloquinolina-quinona","status":"publish","type":"post","link":"https:\/\/www.robertofrancodoamaral.com.br\/blog\/pqq-pirroloquinolina-quinona\/","title":{"rendered":"Pirroloquinolina Quinona ( BioPQQ) : o que \u00e9?"},"content":{"rendered":"<p>Embora o<span style=\"color: #0000ff;\"><strong> pirroloquinolina-quinona ( Biopqq)<\/strong><\/span>\u00a0 n\u00e3o seja visto atualmente como uma vitamina, seu envolvimento nas vias de sinaliza\u00e7\u00e3o celular, particularmente aquelas importantes para a mitocondriog\u00eanese em modelos animais experimentais, pode eventualmente fornecer uma justificativa para definir o <strong>PQQ como vital para a vida.<\/strong><\/p>\n<p>Em animais, Pirroloquinolina\u00a0 \u00e9 relatado para participar de uma gama de fun\u00e7\u00f5es biol\u00f3gicas com benef\u00edcios de sobreviv\u00eancia aparentes<\/p>\n<p>Para que serve a <span style=\"color: #0000ff;\"><strong>pirroloquinolina-quinona ( Biopqq)<\/strong><\/span>\u00a0?<\/p>\n<ul>\n<li>Melhora cognitivas ( INTELECTUAL)<\/li>\n<li>Biogen\u00ease mitocondrial ( forma\u00e7\u00e3o de novas mitoc\u00f4ndrias)<\/li>\n<li>antioxidantes<\/li>\n<li>\u00a0prote\u00e7\u00e3o contra eventos isqu\u00eamicos\u00a0 card\u00edacos ( falta de oxig\u00eanio cora\u00e7\u00e3o levando ao infarto) e neurol\u00f3gicos<\/li>\n<\/ul>\n<p>Os benef\u00edcios do <span style=\"color: #0000ff;\">PQQ<\/span> para a sa\u00fade em humanos foram revisados \u200b\u200brecentemente, incluindo para diabetes, atividade antioxidante, neuroprote\u00e7\u00e3o, cogni\u00e7\u00e3o (\u00a0<a id=\"__tag_734737335\" class=\" bibr popnode tag_hotlink tag_tooltip\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6205492\/#r96\" aria-expanded=\"false\" aria-haspopup=\"true\">96<\/a>\u00a0) e redu\u00e7\u00e3o do n\u00edvel de prote\u00edna C reativa (isto \u00e9, inflama\u00e7\u00e3o).<\/p>\n<p>Al\u00e9m disso, a suplementa\u00e7\u00e3o com <span style=\"color: #0000ff;\">PQQ<\/span> melhorou o potencial antioxidante e diminuiu os n\u00edveis de intermedi\u00e1rios e metab\u00f3litos relacionados \u00e0 mitoc\u00f4ndria na urina, fornecendo suporte para estudos anteriores que demonstraram que o PQQ melhorou a efici\u00eancia mitocondrial (\u00a0<a id=\"__tag_734737291\" class=\" bibr popnode tag_hotlink tag_tooltip\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6205492\/#r97\" aria-expanded=\"false\" aria-haspopup=\"true\">97<\/a>\u00a0).<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1136652\/bin\/biochemj00065-0029.tif\" alt=\"imagem digitalizada da p\u00e1gina 332\" width=\"585\" height=\"780\" \/><\/p>\n<h4 style=\"text-align: center;\"><span style=\"color: #0000ff;\">Possui propriedades vitam\u00ednicas e antioxidantes, associadas a fun\u00e7\u00f5es de <strong>repara\u00e7\u00e3o cognitiva (intelectual)<\/strong>, com importante papel no processo de <strong>envelhecimento<\/strong>, prote\u00e7\u00e3o das c\u00e9lulas nervosas e na estimula\u00e7\u00e3o natural dos n\u00edveis energ\u00e9ticos ligados \u00e0<strong> concentra\u00e7\u00e3<\/strong>o e ao <strong>desempenho<\/strong>.<\/span><\/h4>\n<p>PQQ tamb\u00e9m mostrou induzir biog\u00eanese mitocondrial em baixos n\u00edveis fisiol\u00f3gicos (\u223c250 \u03bcg \/ kg em rato) atrav\u00e9s do coativador-1 \u03b1 do receptor \u03b3 ativado por proliferador (PGC-1\u03b1) em peroxissomos<\/p>\n<hr \/>\n<p style=\"text-align: left;\">As mitoc\u00f4ndrias s\u00e3o as centrais energ\u00e9ticas das c\u00e9lulas. C\u00e9lulas dos indiv\u00edduos jovens cont\u00eam grande n\u00famero de mitoc\u00f4ndrias \u2013 entre 2000 a 2500 por c\u00e9lula \u2013 que funcionam no rendimento m\u00e1ximo.<\/p>\n<p style=\"text-align: left;\">Em idosos, as mitoc\u00f4ndrias s\u00e3o menos numerosas resultando em perda de energia, problemas cognitivos e degrada\u00e7\u00e3o celular acelerada.<\/p>\n<p style=\"text-align: left;\"><span style=\"color: #0000ff;\"><strong> Este grande d\u00e9ficit energ\u00e9tico est\u00e1 implicado em praticamente todas as doen\u00e7as degenerativas associadas ao envelhecimento.<\/strong><\/span><\/p>\n<p style=\"text-align: left;\">Em 2010, pesquisadores da Universidade da Calif\u00f3rnia na cidade de Davis, lan\u00e7aram um artigo de revis\u00e3o mostrando de modo muito significativo que a <strong>PQQ<\/strong> n\u00e3o s\u00f3 protege a mitoc\u00f4ndria do estresse oxidativo, mas promove a gera\u00e7\u00e3o espont\u00e2nea de novas mitoc\u00f4ndrias (biog\u00eanese mitocondrial) nas c\u00e9lulas em processo de envelhecimento.<\/p>\n<figure id=\"attachment_860\" aria-describedby=\"caption-attachment-860\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-860 \" src=\"https:\/\/www.robertofrancodoamaral.com.br\/blog\/wp-content\/uploads\/2013\/07\/mitochondrial-myopathy-pqq.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/www.robertofrancodoamaral.com.br\/blog\/wp-content\/uploads\/2013\/07\/mitochondrial-myopathy-pqq.jpg 500w, https:\/\/www.robertofrancodoamaral.com.br\/blog\/wp-content\/uploads\/2013\/07\/mitochondrial-myopathy-pqq-150x150.jpg 150w, https:\/\/www.robertofrancodoamaral.com.br\/blog\/wp-content\/uploads\/2013\/07\/mitochondrial-myopathy-pqq-300x300.jpg 300w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-860\" class=\"wp-caption-text\">PQQ e mitoc\u00f4ndria<\/figcaption><\/figure>\n<p style=\"text-align: left;\"><span style=\"color: #0000ff;\"><strong>Diversos estudos t\u00eam demonstrado o efeito neuroprotetor da pirroloquinolina-quinona ( Biopqq)\u00a0 sobre a mem\u00f3ria e o processo de racioc\u00ednio (cogni\u00e7\u00e3o) no envelhecimento de animais experimentais e seres humano<\/strong>s.<\/span><\/p>\n<p style=\"text-align: left;\">Ohwada e colaboradores em 2008, demonstraram que a PQQ reverte o comprometimento da cogni\u00e7\u00e3o causado pelo<strong> estresse oxidativo<\/strong> cr\u00f4nico em modelos animais e melhora o desempenho em <strong>testes de mem\u00f3ria.<\/strong><\/p>\n<p><img decoding=\"async\" class=\"\" src=\"https:\/\/clinicaconceitosaude.com.br\/wp-content\/uploads\/2019\/04\/stress_oxi_01.png\" alt=\"Observatorio Internacional de Estresse Oxidativo \u2013 Cl\u00ednica Conceito Sa\u00fade\" width=\"559\" height=\"212\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"\" src=\"https:\/\/blog.vitalatman.com.br\/wp-content\/uploads\/2017\/01\/estress-oxidativo-3.jpg\" alt=\"Reduce Oxidative Stress | Protandim UK - Vital \u00c2tman Blog\" width=\"577\" height=\"249\" \/><\/p>\n<p style=\"text-align: left;\">A suplementa\u00e7\u00e3o de PQQ estimula a produ\u00e7\u00e3o e libera\u00e7\u00e3o de fatores de crescimento de nervos nas c\u00e9lulas que sustentam os neur\u00f4nios no c\u00e9rebro, denominadas c\u00e9lulas <strong>neurogliais<\/strong>, um poss\u00edvel mecanismo para a melhoria da fun\u00e7\u00e3o da mem\u00f3ria produzida em seres humanos e ratos senescentes ( idosos)<\/p>\n<p style=\"text-align: left;\">Em um artigo publicado na Science, ratos alimentados com uma dieta desprovida de <span style=\"color: #0000ff;\"><strong>pirroloquinolina-quinona ( Biopqq)<\/strong><\/span>\u00a0\u00a0cresceram deficientemente, n\u00e3o conseguiram se reproduzir, e desenvolveram <strong>osteoartrite.<\/strong><\/p>\n<p style=\"text-align: left;\">De acordo com o artigo publicado no <i>Biological &amp; Pharmaceutical Bulletin<\/i> pelo Dr. Nunome e colaboradores em 2008, a PQQ demonstrou atividade contra a auto-oxida\u00e7\u00e3o da prote\u00edna DJ-1, tamb\u00e9m chamada \u201cProte\u00edna 7 da doen\u00e7a de <strong>Parkinson<\/strong>\u201d, uma prote\u00edna sinalizadora celular, que desempenha fun\u00e7\u00f5es na fertiliza\u00e7\u00e3o, na promo\u00e7\u00e3o do crescimento e transforma\u00e7\u00e3o celular e atenua o estresse oxidativo nos neur\u00f4nios.<\/p>\n<hr \/>\n<h3><span style=\"color: #ff6600;\"><strong><span style=\"color: #0000ff;\">Seus efeitos antioxidantes\u00a0 s\u00e3o potencializados\u00a0 com estes tr\u00eas nutrientes otimizadores da fun\u00e7\u00e3o mitocondrial e cerebral:<\/span><\/strong><\/span><\/h3>\n<ol>\n<li style=\"text-align: left;\"><a href=\"https:\/\/www.robertofrancodoamaral.com.br\/blog\/acido-lipoico\/\"><span style=\"color: #003300;\">\u00c1cido Alfa-Lip\u00f3ico\u00a0<\/span><\/a><\/li>\n<li style=\"text-align: left;\"><span style=\"color: #003300;\"> Acetil L-carnitina <\/span><\/li>\n<li style=\"text-align: left;\"><a href=\"https:\/\/www.amazon.com.br\/Coenzima-Q10-com-%C3%94mega-Essential\/dp\/B07ZG51GV4\/ref=as_li_ss_il?__mk_pt_BR=%C3%85M%C3%85%C5%BD%C3%95%C3%91&amp;crid=QVMG1CYN0P4F&amp;dchild=1&amp;keywords=coenzima+q10+essential&amp;qid=1592660550&amp;sprefix=coe,aps,288&amp;sr=8-1&amp;linkCode=li2&amp;tag=amaraleoberto-20&amp;linkId=31cee4ce48786e07ecf248aef4c12f4a&amp;language=pt_BR\"><span style=\"color: #ff6600;\"><span style=\"color: #0000ff;\"><span style=\"color: #003300;\">Coenzima Q10<\/span><\/span><\/span><\/a><\/li>\n<\/ol>\n<p><img loading=\"lazy\" decoding=\"async\" style=\"border: none !important; margin: 0px !important;\" src=\"https:\/\/ir-br.amazon-adsystem.com\/e\/ir?t=amaraleoberto-20&amp;language=pt_BR&amp;l=li2&amp;o=33&amp;a=B07ZG51GV4\" alt=\"\" width=\"1\" height=\"1\" border=\"0\" \/><\/p>\n<hr \/>\n<p style=\"text-align: left;\">Outro estudo japon\u00eas realizado em 2007 mostrou que a<strong> PQQ<\/strong>, tomada diariamente, melhorava a mem\u00f3ria, a aten\u00e7\u00e3o e as fun\u00e7\u00f5es cognitivas; os desempenhos do grupo que tomou o suplemento de <strong>PQQ<\/strong> foram duas vezes superiores aos do grupo que tomou o placebo.<\/p>\n<p style=\"text-align: left;\">A tomada conjugada de CoQ10 amplificou ainda os desempenhos nos testes de mem\u00f3ria.<\/p>\n<p style=\"text-align: left;\">Portanto os estudos concluem que a PQQ e a CoQ10, tomadas simultaneamente, melhoram o estado antioxidante e a sa\u00fade mitocondrial por mecanismos complementares.<\/p>\n<p style=\"text-align: left;\">\u00c9 importante salientar, que apesar dos benef\u00edcios comprovados cientificamente, a utiliza\u00e7\u00e3o de tais subst\u00e2ncias deve ser feita sob orienta\u00e7\u00e3o e supervis\u00e3o de um m\u00e9dico especialista.<\/p>\n<hr \/>\n<p><span style=\"color: #0000ff;\"><strong>Efeito do suplemento pirroloquinolina quinona (BioPQQ \u2122) nas fun\u00e7\u00f5es cognitiva:s<\/strong><\/span><\/p>\n<p>A pirroloquinolina quinona (PQQ) \u00e9 um composto de quinona identificado pela primeira vez em 1979.<\/p>\n<p>Foi relatado que ratos alimentados com uma dieta suplementada com PQQ mostraram melhor capacidade de aprendizagem do que os controles, sugerindo que o PQQ pode ser \u00fatil para melhorar a mem\u00f3ria em humanos.<\/p>\n<p>No presente estudo, um estudo randomizado, controlado com placebo e duplo-cego para examinar o efeito do sal diss\u00f3dico PQQ (BioPQQ \u2122) nas fun\u00e7\u00f5es cognitivas foi conduzido com 41 idosos saud\u00e1veis.<\/p>\n<p>Os indiv\u00edduos receberam 20 mg de BioPQQ \u2122 por via oral ou placebo por 12 semanas.<\/p>\n<p>Para as fun\u00e7\u00f5es cognitivas, foram avaliadas a aten\u00e7\u00e3o seletiva pelo teste de Stroop e Stroop reverso e a fun\u00e7\u00e3o cognitiva visoespacial pelo laptop Touch M.<\/p>\n<p>Os resultados sugerem que o PQQ pode prevenir a redu\u00e7\u00e3o da fun\u00e7\u00e3o cerebral em pessoas idosas, especialmente na aten\u00e7\u00e3o e na mem\u00f3ria de trabalho. a pontua\u00e7\u00e3o aumentou significativamente.<\/p>\n<hr \/>\n<div class=\"css-1u22pos\">\n<p><span style=\"color: #0000ff;\"><strong>Pirroloquinolina-quinona ( Biopqq)\u00a0 e esteatose hep\u00e1tica ( gordura no f\u00edgado)<\/strong><\/span><\/p>\n<p>Os pesquisadores descobriram que um composto encontrado no kiwi, aipo e mam\u00e3o &#8211; chamado pirroloquinolina quinona (PQQ) &#8211; evitou a progress\u00e3o da doen\u00e7a hep\u00e1tica gordurosa n\u00e3o alco\u00f3lica (DHGNA\u00a0 ) em camundongos cujas m\u00e3es foram alimentadas com uma dieta rica em gordura.<\/p>\n<p>L\u00edder do estudo Karen Jonscher, Ph.D.\u00a0&#8211; um professor associado de anestesiologia da Universidade do Colorado Anschutz Medical Campus em Aurora, CO &#8211; e seus colegas relataram recentemente suas\u00a0<a class=\"content-link css-29oowu\" href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hep4.1139\/full\" target=\"_blank\" rel=\"noopener noreferrer\">descobertas<\/a>\u00a0na revista\u00a0<em>Hepatology Communications<\/em>\u00a0.<\/p>\n<p>DHGNA \u00e9 <a class=\"content-link css-29oowu\" href=\"https:\/\/www.niddk.nih.gov\/health-information\/liver-disease\/nafld-nash\/definition-facts\" target=\"_blank\" rel=\"noopener noreferrer\">definida<\/a>\u00a0como um ac\u00famulo de<strong> gordura no f\u00edgado<\/strong> que n\u00e3o \u00e9 causado pelo consumo de \u00e1lcool.<\/p>\n<\/div>\n<div class=\"css-0\">\n<p><strong>\u201cCada vez mais, as evid\u00eancias sugerem que a exposi\u00e7\u00e3o \u00e0 obesidade materna cria um ambiente inflamat\u00f3rio no \u00fatero\u201d, diz Jonscher.\u00a0<\/strong><\/p>\n<p><strong>\u201cIsso leva a interrup\u00e7\u00f5es p\u00f3s-natais de longa dura\u00e7\u00e3o do sistema imunol\u00f3gico inato da prole e da sa\u00fade das bact\u00e9rias intestinais, o que pode aumentar o risco de desenvolvimento de doen\u00e7a hep\u00e1tica gordurosa\u201d.<\/strong><\/p>\n<p>Em um\u00a0<a class=\"content-link css-29oowu\" href=\"http:\/\/www.fasebj.org\/doi\/abs\/10.1096\/fj.201600906R\" target=\"_blank\" rel=\"noopener noreferrer\">estudo anterior com camundongos<\/a>\u00a0, os pesquisadores descobriram que a suplementa\u00e7\u00e3o de PQQ em camundongas gr\u00e1vidas e obesas evitou o ac\u00famulo leve de gordura no f\u00edgado dos filhos.<\/p>\n<p>PQQ \u00e9 um composto presente em alimentos \u00e0 base de plantas &#8211; incluindo kiwi, piment\u00e3o verde, aipo, salsa e mam\u00e3o &#8211; e leite materno.\u00a0PQQ \u00e9 um\u00a0<a class=\"content-link css-29oowu keywords\" title=\"Antioxidantes: benef\u00edcios para a sa\u00fade e informa\u00e7\u00f5es nutricionais\" href=\"https:\/\/www.medicalnewstoday.com\/articles\/301506.php\">antioxidante<\/a>\u00a0.\u00a0Isso significa que pode ajudar a proteger nosso corpo contra\u00a0os radicais livres\u00a0, que s\u00e3o mol\u00e9culas sem carga que podem danificar o DNA e outros componentes celulares.<\/p>\n<p>Para este \u00faltimo estudo, Jonscher e colegas decidiram determinar se a suplementa\u00e7\u00e3o materna com PQQ pode ajudar a prevenir o desenvolvimento de NAFLD na prole.<\/p>\n<hr \/>\n<\/div>\n<p><strong><span style=\"color: #0000ff;\">FORMAS DE <\/span><span style=\"color: #0000ff;\">US<\/span><span style=\"color: #0000ff;\">O:<\/span><\/strong><\/p>\n<p style=\"text-align: left;\"><span style=\"color: #003300;\">L \u00a0Carnitina, Coenzima Q10, Pirroloquinolino podem ser usados na forma oral, sublingual e injet\u00e1vel<\/span><\/p>\n<h6 style=\"text-align: left;\"><span style=\"color: #003300;\"><strong>Caso deseje fazer na forma injet\u00e1vel entre\u00a0 em contato pelo\u00a0 Whatssapp da Cl\u00ednica Franco do Amaral\u00a0 <a style=\"color: #003300;\" href=\"http:\/\/clinicafrancodoamaral.com.br\/\">http:\/\/clinicafrancodoamaral.com.br\/<\/a><\/strong><\/span><\/h6>\n<h6><\/h6>\n<hr \/>\n<h3>REFER\u00caNCIAS :<\/h3>\n<ul>\n<li style=\"text-align: justify;\">\n<h6>Chowanadisai, W; Bauerly, KA; Tchaparian, E; Wong, A; Cortopassi, GA; Rucker, RB (2010 Jan). &#8220;Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression&#8221;. <i>Journal of Biological Chemistry<\/i> <b>285<\/b> (1): 142\u201352.<\/h6>\n<\/li>\n<li style=\"text-align: justify;\">\n<h6>Murase, K; Hattori, A; Kohno, M; Hayashi, K (1993). &#8220;Stimulation of nerve growth factor synthesis\/secretion in mouse astroglial cells by coenzymes&#8221;. <i>Biochemistry and molecular biology international<\/i> <b>30<\/b> (4): 615\u201321<\/h6>\n<\/li>\n<li style=\"text-align: justify;\">\n<h6>Takatsu, H; Owada, K; Abe, K; Nakano, M; Urano, S (2009). &#8220;Effect of vitamin E on learning and memory deficit in aged rats&#8221;. <i>Journal of nutritional science and vitaminology<\/i> <b>55<\/b> (5): 389\u201393<\/h6>\n<\/li>\n<li style=\"text-align: justify;\">\n<h6>&#8220;Effect of pyrroloquinoline quinone (PQQ) on mental status of middle-aged and elderly persons&#8221;. <i>Food Style 21<\/i> <b>13<\/b> (7): 50\u201352. 2009.<\/h6>\n<\/li>\n<li style=\"text-align: justify;\">\n<h6>Nakano M, Ubukata K, Yamamoto T, Yamaguchi H. Effect of Pyrroloquinoline Quinone (PQQ) on Mental Status of Middle-Aged and Elderly Persons.<\/h6>\n<\/li>\n<li style=\"text-align: justify;\">\n<h6>Scanlon J M; Aizenman E; Reynolds I J. Effects of pyrroloquinoline quinone on glutamateinduced production of reactive oxygen species in neurons. European journal of pharmacology 1997;326(1):67-74<\/h6>\n<\/li>\n<li style=\"text-align: justify;\">\n<h6>Zhang Y, Rosenberg PA. The essential nutrient pyrroloquinoline quinone may act as a neuroprotectant by suppressing peroxynitrite formation. Eur. J Neorosci, 16: 1015-1024, 2002.<\/h6>\n<\/li>\n<li style=\"text-align: justify;\">\n<h6>Li G, Jack CR, Yang XF, Yang ES. Diet supplement CoQ10 delays brain atrophy in aged transgenic mice with mutations in the amyloid precursor protein: an in vivo volume MRI study. Biofactors. 2008;32(1-4):169-78<\/h6>\n<\/li>\n<li style=\"text-align: justify;\">\n<h6>Liu J. The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving ageassociated mitochondrial and cognitive dysfunction: an overview. Neurochem Res. 2008<\/h6>\n<\/li>\n<li style=\"text-align: justify;\">\n<h6>Jan;33(1):194-203.<\/h6>\n<\/li>\n<li style=\"text-align: justify;\">\n<h6>McDonald SR, Sohal RS, Forster MJ. Concurrent administration of coenzyme Q10 and alphatocopherol improves learning in aged mice. Free Radic Biol Med. 2005 Mar 15;38(6):729-36.<\/h6>\n<\/li>\n<li style=\"text-align: justify;\">\n<h6>Ishrat T, Khan MB, Hoda MN, Yousuf S, Ahmad M, Ansari MA, Ahmad AS, Islam F. Coenzyme Q10 modulates cognitive impairment against intracerebroventricular injection of streptozotocin in rats. Behav Brain Res. 2006 Jul 15;171(1):9-16.<\/h6>\n<\/li>\n<li style=\"text-align: justify;\">\n<h6>http:\/\/www.medicinacomplementar.com.br\/biblioteca\/pdfs\/Fitoterapia\/fi-0392.pdf<\/h6>\n<\/li>\n<li>Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ\u2122) on Cognitive Functions<br \/>\nYuji Itoh\u00a01,\u00a0Kyoko Hine\u00a01,\u00a0Hiroshi Miura\u00a01,\u00a0Tatsuo Uetake\u00a02,\u00a0Masahiko Nakano\u00a03,\u00a0Naohiro Takemura\u00a04,\u00a0Kaoru Sakatani\u00a04\u00a05<\/li>\n<li>High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate modelJun Ma, Amanda L. Prince, David Bader, Min Hu, Radhika Ganu, Karalee Baquero, Peter Blundell, R. Alan Harris, Antonio E. Frias, Kevin L. Grove &amp;\u00a0Kjersti M. Aagaard<\/li>\n<li>Potential physiological importance of pyrroloquinoline quinoneRobert Rucker\u00a01,\u00a0Winyoo Chowanadisai,\u00a0Masahiko Nakano<\/li>\n<li>Levels of pyrroloquinoline quinone in various foods. T Kumazawa,\u00a0K Sato,\u00a0H Seno,\u00a0A Ishii, and\u00a0O Suzuki<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Embora o pirroloquinolina-quinona ( Biopqq)\u00a0 n\u00e3o seja visto atualmente como uma vitamina, seu envolvimento nas vias de sinaliza\u00e7\u00e3o celular, particularmente aquelas importantes para a mitocondriog\u00eanese em modelos animais experimentais, pode eventualmente fornecer uma justificativa para definir o PQQ como vital para a vida. Em animais, Pirroloquinolina\u00a0 \u00e9 relatado para participar de uma gama de fun\u00e7\u00f5es [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":5028,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[3,667,661,650],"tags":[146,147,148,149,151,153,154,156,157],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Pirroloquinolina Quinona ( BioPQQ) : o que \u00e9? - Dr. Roberto Franco do Amaral Neto<\/title>\n<meta name=\"description\" content=\"A pirroloquinolina-quinona ( Biopqq)\u00a0tem a\u00e7\u00f5es antioxidantes bem como na produ\u00e7\u00e3o de energia pelo organismo.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.robertofrancodoamaral.com.br\/blog\/pqq-pirroloquinolina-quinona\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pirroloquinolina Quinona ( BioPQQ) : o que \u00e9? 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