{"id":12030,"date":"2025-10-21T19:49:21","date_gmt":"2025-10-21T22:49:21","guid":{"rendered":"https:\/\/www.robertofrancodoamaral.com.br\/blog\/?p=12030"},"modified":"2026-02-05T03:28:06","modified_gmt":"2026-02-05T06:28:06","slug":"efeitos-da-testosterona-no-coracao","status":"publish","type":"post","link":"https:\/\/www.robertofrancodoamaral.com.br\/blog\/efeitos-da-testosterona-no-coracao\/","title":{"rendered":"Efeitos da Testosterona no Cora\u00e7\u00e3o e na Sa\u00fade Mental."},"content":{"rendered":"<article class=\"text-token-text-primary w-full focus:outline-none [--shadow-height:45px] has-data-writing-block:pointer-events-none has-data-writing-block:-mt-(--shadow-height) has-data-writing-block:pt-(--shadow-height) [&amp;:has([data-writing-block])&gt;*]:pointer-events-auto scroll-mt-[calc(var(--header-height)+min(200px,max(70px,20svh)))]\" dir=\"auto\" tabindex=\"-1\" data-turn-id=\"df186381-f924-431a-914f-360ca19b2bcd\" data-testid=\"conversation-turn-4\" data-scroll-anchor=\"false\" data-turn=\"assistant\">\n<div class=\"text-base my-auto mx-auto [--thread-content-margin:--spacing(4)] thread-sm:[--thread-content-margin:--spacing(6)] thread-lg:[--thread-content-margin:--spacing(16)] px-(--thread-content-margin)\">\n<div class=\"[--thread-content-max-width:40rem] thread-lg:[--thread-content-max-width:48rem] mx-auto max-w-(--thread-content-max-width) flex-1 group\/turn-messages focus-visible:outline-hidden relative flex w-full min-w-0 flex-col agent-turn\" tabindex=\"-1\">\n<div class=\"flex max-w-full flex-col grow\">\n<div class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal [.text-message+&amp;]:mt-1\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"df186381-f924-431a-914f-360ca19b2bcd\" data-message-model-slug=\"gpt-5\">\n<div class=\"streaming-animation markdown prose dark:prose-invert w-full break-words light markdown-new-styling\">\n<h1 data-start=\"638\" data-end=\"939\">____________________________________<\/h1>\n<figure id=\"attachment_12370\" aria-describedby=\"caption-attachment-12370\" style=\"width: 1200px\" class=\"wp-caption alignnone\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-12370\" src=\"http:\/\/www.robertofrancodoamaral.com.br\/blog\/wp-content\/uploads\/2025\/10\/robertofrancodoamaral.com.br-efeitos-da-testosterona-no-coracao-testosterona-e-coracao.jpg\" alt=\"estosterona e cora\u00e7\u00e3o\" width=\"1200\" height=\"800\" srcset=\"https:\/\/www.robertofrancodoamaral.com.br\/blog\/wp-content\/uploads\/2025\/10\/robertofrancodoamaral.com.br-efeitos-da-testosterona-no-coracao-testosterona-e-coracao.jpg 1200w, https:\/\/www.robertofrancodoamaral.com.br\/blog\/wp-content\/uploads\/2025\/10\/robertofrancodoamaral.com.br-efeitos-da-testosterona-no-coracao-testosterona-e-coracao-300x200.jpg 300w, https:\/\/www.robertofrancodoamaral.com.br\/blog\/wp-content\/uploads\/2025\/10\/robertofrancodoamaral.com.br-efeitos-da-testosterona-no-coracao-testosterona-e-coracao-1024x683.jpg 1024w, https:\/\/www.robertofrancodoamaral.com.br\/blog\/wp-content\/uploads\/2025\/10\/robertofrancodoamaral.com.br-efeitos-da-testosterona-no-coracao-testosterona-e-coracao-768x512.jpg 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-12370\" class=\"wp-caption-text\">testosterona e cora\u00e7\u00e3o<\/figcaption><\/figure>\n<h1 data-start=\"638\" data-end=\"939\"><span style=\"color: #0000ff;\">Com o envelhecimento h\u00e1 um incremento na preval\u00eancia de doen\u00e7as cardiovasculares<\/span><\/h1>\n<p data-start=\"638\" data-end=\"939\">\u00a0Paralelamente, ocorre redu\u00e7\u00e3o progressiva na concentra\u00e7\u00e3o\u00a0 dos horm\u00f4nios sexuais masculinos, sendo que nas faixas et\u00e1rias mais avan\u00e7adas a testosterona \u00e9 reduzida em, aproximadamente, 15 a 20% \u00a0dos indiv\u00edduos.<\/p>\n<p data-start=\"638\" data-end=\"939\">Os receptores de testosterona\u00a0 distribuem-se amplamente nos tecidos vasculares, como<\/p>\n<ul>\n<li data-start=\"638\" data-end=\"939\">art\u00e9ria aorta<\/li>\n<li data-start=\"638\" data-end=\"939\">vasculatura perif\u00e9rica<\/li>\n<li data-start=\"638\" data-end=\"939\">c\u00e9lulas atriais e ventriculares .<\/li>\n<\/ul>\n<p>Dessa forma, \u00e9 poss\u00edvel supor que os horm\u00f4nios sexuais no homem exer\u00e7am influ\u00eancia no desenvolvimento das doen\u00e7as cardiovasculares..<\/p>\n<\/div>\n<div class=\"streaming-animation markdown prose dark:prose-invert w-full break-words light markdown-new-styling\">\n<p data-start=\"941\" data-end=\"1183\">A testosterona \u00e9 o principal horm\u00f4nio sexual masculino, produzida nas <strong data-start=\"1011\" data-end=\"1032\">c\u00e9lulas de Leydig<\/strong>, a partir do colesterol.<\/p>\n<p data-start=\"941\" data-end=\"1183\">Al\u00e9m de manter caracter\u00edsticas sexuais e massa muscular, ela <strong data-start=\"1119\" data-end=\"1182\">atua diretamente no cora\u00e7\u00e3o, vasos sangu\u00edneos e metabolismo<\/strong>.<\/p>\n<hr data-start=\"1185\" data-end=\"1188\" \/>\n<h2 data-start=\"1190\" data-end=\"1235\"><span style=\"color: #3366ff;\">Testosterona e o sistema cardiovascular:<\/span><\/h2>\n<p><span style=\"color: #ff6600;\">\u00a0Fun\u00e7\u00e3o card\u00edaca<\/span><\/p>\n<p data-start=\"1260\" data-end=\"1606\">Estudos experimentais demonstram que a testosterona exerce um <strong data-start=\"1322\" data-end=\"1374\">efeito\u00a0 direto sobre o m\u00fasculo card\u00edaco<\/strong>, aumentando a for\u00e7a de contra\u00e7\u00e3o e a efici\u00eancia do bombeamento de sangue.<\/p>\n<p data-start=\"1260\" data-end=\"1606\">A defici\u00eancia hormonal est\u00e1 associada \u00e0 <strong data-start=\"1491\" data-end=\"1542\">redu\u00e7\u00e3o da fra\u00e7\u00e3o de eje\u00e7\u00e3o, do d\u00e9bito card\u00edaco<\/strong> e at\u00e9 \u00e0 <strong data-start=\"1551\" data-end=\"1572\">caquexia card\u00edaca<\/strong> em casos graves de insufici\u00eancia.<\/p>\n<p data-start=\"1608\" data-end=\"1770\">Reposi\u00e7\u00f5es adequadas tendem a <strong data-start=\"1638\" data-end=\"1673\">restaurar o desempenho card\u00edaco<\/strong> e melhorar a qualidade de vida em pacientes com <strong data-start=\"1722\" data-end=\"1769\">baixa testosterona e insufici\u00eancia card\u00edaca<\/strong>.<\/p>\n<hr data-start=\"1772\" data-end=\"1775\" \/>\n<p><span style=\"color: #ff6600;\">\u00a0Fun\u00e7\u00e3o vascular<\/span><\/p>\n<p data-start=\"1800\" data-end=\"2147\">A testosterona atua sobre o <strong data-start=\"1828\" data-end=\"1841\">endot\u00e9lio<\/strong> (camada interna dos vasos), estimulando a <strong data-start=\"1884\" data-end=\"1901\">vasodilata\u00e7\u00e3o<\/strong> e o <strong data-start=\"1906\" data-end=\"1937\">fluxo sangu\u00edneo coronariano<\/strong>.<\/p>\n<p data-start=\"1800\" data-end=\"2147\"><br data-start=\"1938\" data-end=\"1941\" \/>Estudos cl\u00ednicos mostraram que pacientes com <strong data-start=\"1986\" data-end=\"2008\">doen\u00e7a coronariana<\/strong> e n\u00edveis baixos de testosterona apresentaram <strong data-start=\"2054\" data-end=\"2077\">redu\u00e7\u00e3o da isquemia<\/strong> ap\u00f3s terapia com testosterona \u2014 tanto endovenosa quanto transd\u00e9rmica.<\/p>\n<p data-start=\"2149\" data-end=\"2263\">Esses achados indicam um poss\u00edvel <strong data-start=\"2183\" data-end=\"2211\">efeito protetor vascular<\/strong> quando o horm\u00f4nio \u00e9 mantido em n\u00edveis fisiol\u00f3gicos.<\/p>\n<hr data-start=\"2839\" data-end=\"2842\" \/>\n<h2 data-start=\"2844\" data-end=\"2884\"><span style=\"color: #3366ff;\">Efeitos na coagula\u00e7\u00e3o (hemostasia)<\/span><\/h2>\n<p data-start=\"2885\" data-end=\"3179\">A testosterona aumenta a <strong data-start=\"2910\" data-end=\"2937\">atividade fibrinol\u00edtica<\/strong> \u2014 mecanismo natural de dissolu\u00e7\u00e3o de co\u00e1gulos \u2014 e melhora o equil\u00edbrio entre <strong data-start=\"3015\" data-end=\"3051\">forma\u00e7\u00e3o e degrada\u00e7\u00e3o de trombos<\/strong>.<\/p>\n<p data-start=\"2885\" data-end=\"3179\">No entanto, o <strong data-start=\"3069\" data-end=\"3095\">abuso de anabolizantes<\/strong> em doses excessivvas pode inverter esse efeito, favorecendo a <strong data-start=\"3137\" data-end=\"3178\">hipercoagula\u00e7\u00e3o e eventos tromb\u00f3ticos por aumento da viscosidade sangu\u00ednea<\/strong><\/p>\n<hr data-start=\"3181\" data-end=\"3184\" \/>\n<h2 data-start=\"3186\" data-end=\"3243\"><span style=\"color: #3366ff;\">Reposi\u00e7\u00e3o de testosterona: indica\u00e7\u00f5es e vias de uso<\/span><\/h2>\n<p>Indica\u00e7\u00f5es principais:<\/p>\n<p data-start=\"3273\" data-end=\"3395\">A terapia de reposi\u00e7\u00e3o \u00e9 indicada em casos de <strong data-start=\"3319\" data-end=\"3375\">hipogonadismo cl\u00ednico e laboratorialmente comprovado<\/strong>, com sintomas como:<\/p>\n<ul data-start=\"3396\" data-end=\"3524\">\n<li data-start=\"3396\" data-end=\"3418\">\n<p data-start=\"3398\" data-end=\"3418\">Cansa\u00e7o\u00a0 persistente<\/p>\n<\/li>\n<li data-start=\"3419\" data-end=\"3459\">\n<p data-start=\"3421\" data-end=\"3459\">Redu\u00e7\u00e3o da libido e disfun\u00e7\u00e3o er\u00e9til<\/p>\n<\/li>\n<li data-start=\"3460\" data-end=\"3495\">\n<p data-start=\"3462\" data-end=\"3495\">Perda de massa muscular e for\u00e7a<\/p>\n<\/li>\n<li data-start=\"3496\" data-end=\"3524\">\n<p data-start=\"3498\" data-end=\"3524\">Altera\u00e7\u00f5es de humor e sono<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"3526\" data-end=\"3617\">Al\u00e9m disso, h\u00e1 evid\u00eancias de benef\u00edcios na <strong data-start=\"3569\" data-end=\"3616\">sa\u00fade \u00f3ssea, composi\u00e7\u00e3o corporal e cogni\u00e7\u00e3o<\/strong>.<\/p>\n<hr data-start=\"3619\" data-end=\"3622\" \/>\n<p><span style=\"color: #ff6600;\">Formas de administra\u00e7\u00e3o<\/span><\/p>\n<p data-start=\"3656\" data-end=\"3701\"><strong data-start=\"3656\" data-end=\"3699\">1. Injet\u00e1vel (Cipionato de testosterona ( CIFARMA ou DEPOSTERON) ,\u00a0 DURATESTON,\u00a0 Undecilato de testosterona 250mg\/ml &#8211; 4ml )<\/strong><\/p>\n<ul data-start=\"3702\" data-end=\"3786\">\n<li data-start=\"3702\" data-end=\"3726\">\n<p data-start=\"3704\" data-end=\"3726\">Libera\u00e7\u00e3o prolongada<\/p>\n<\/li>\n<li data-start=\"3727\" data-end=\"3751\">\n<p data-start=\"3729\" data-end=\"3751\">Deposteron ( cipionato de testosterona) :\u00a0 A\u00e7\u00e3o de 10 a 14 dias<\/p>\n<\/li>\n<li data-start=\"3727\" data-end=\"3751\"><img decoding=\"async\" class=\"wp-image-12031 size-full\" src=\"http:\/\/www.robertofrancodoamaral.com.br\/blog\/wp-content\/uploads\/2025\/10\/robertofrancodoamaral.com.br-efeitos-da-testosterona-no-coracao-cipionato-de-testosterona.jpg\" alt=\"\" width=\"298\" height=\"169\" \/><\/li>\n<li data-start=\"3727\" data-end=\"3751\">\n<p data-start=\"3729\" data-end=\"3751\">Duratesaton:\u00a0 de 14 a 21 dias<\/p>\n<\/li>\n<li data-start=\"3727\" data-end=\"3751\">Undecilato de testsoterona ( Nebido, Hormus, Atesto)\u00a0 &#8211; 45 a 60 dias<\/li>\n<li data-start=\"3752\" data-end=\"3786\">\n<p data-start=\"3754\" data-end=\"3786\">Boa absor\u00e7\u00e3o e boa resposta<\/p>\n<\/li>\n<li data-start=\"3752\" data-end=\"3786\">Durateston e Deposteron far\u00e3o picos de absor\u00e7ao durantre a libera\u00e7ao assim,proximo a aplica\u00e7ao, o n\u00edvel de testosterona no sangue pode estar bem mais alto que no d\u00e9cimo dia por exemplo\u00a0 \u00a0&#8211; como visto no gr\u00e1fico acima<\/li>\n<\/ul>\n<p data-start=\"3788\" data-end=\"3843\"><strong data-start=\"3788\" data-end=\"3841\">2. Oral (Undecanoato de Testosterona \u2013 Androxon\u00ae)<\/strong><\/p>\n<ul data-start=\"3844\" data-end=\"3907\">\n<li data-start=\"3844\" data-end=\"3864\">\n<p data-start=\"3846\" data-end=\"3864\">N\u00e3o hepatot\u00f3xico<\/p>\n<\/li>\n<li data-start=\"3865\" data-end=\"3907\">\n<p data-start=\"3867\" data-end=\"3907\">Menor estabilidade de n\u00edveis hormonais<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"3909\" data-end=\"3947\"><strong data-start=\"3909\" data-end=\"3945\">3. Transd\u00e9rmica &#8211; Manipulada com dose individualizada , Androgel\u00a0 50mg \/ sach\u00ea ( 30sach\u00eas) , Androgel pump,\u00a0 16,2mg\/pump<\/strong><\/p>\n<ul data-start=\"3948\" data-end=\"4075\">\n<li data-start=\"3948\" data-end=\"3988\">\n<p data-start=\"3950\" data-end=\"3988\">Reproduz n\u00edveis fisiol\u00f3gicos diurnos<\/p>\n<\/li>\n<li data-start=\"3989\" data-end=\"4028\">\n<p data-start=\"3991\" data-end=\"4028\">Maior conforto e absor\u00e7\u00e3o constante<\/p>\n<\/li>\n<li data-start=\"4029\" data-end=\"4075\">\n<p data-start=\"4031\" data-end=\"4075\">Maior custo e risco de transfer\u00eancia cut\u00e2nea<\/p>\n<\/li>\n<\/ul>\n<figure style=\"width: 636px\" class=\"wp-caption alignnone\"><img decoding=\"async\" src=\"https:\/\/i0.wp.com\/d3043uog1ad1l6.cloudfront.net\/uploads\/2022\/10\/medicacoes.png?resize=636%2C441&amp;ssl=1\" alt=\"tipos de testerona\" width=\"636\" height=\"441\" \/><figcaption class=\"wp-caption-text\">TIPOS DE TESTOSTERONA VENDIDAS DE FORMA LEGAL<\/figcaption><\/figure>\n<p><a href=\"https:\/\/sanarmed.com\/reposicao-de-testosterona-evidencias-sobre-riscos-e-beneficios-em-homens-idosos-colunistapremium\/\">FONTE: SANAR MED<\/a><\/p>\n<hr data-start=\"4077\" data-end=\"4080\" \/>\n<h2 data-start=\"4082\" data-end=\"4113\"><span style=\"color: #3366ff;\">Riscos e efeitos adversos:<\/span><\/h2>\n<p data-start=\"4115\" data-end=\"4174\">O uso inadequado ou em doses suprafisiol\u00f3gicas pode causar:<\/p>\n<ul data-start=\"4175\" data-end=\"4331\">\n<li data-start=\"4175\" data-end=\"4232\">\n<p data-start=\"4177\" data-end=\"4232\"><strong data-start=\"4177\" data-end=\"4230\">Acne, oleosidade, ginecomastia e reten\u00e7\u00e3o h\u00eddrica\u00a0 ( princilmente se n\u00e3o evitar conves\u00e3o de testosterona em estradiol)<\/strong><\/p>\n<\/li>\n<li data-start=\"4233\" data-end=\"4276\">\n<p data-start=\"4235\" data-end=\"4276\"><strong data-start=\"4235\" data-end=\"4274\">Agressividade e altera\u00e7\u00f5es de humor ( pouco comum)<\/strong><\/p>\n<\/li>\n<li data-start=\"4277\" data-end=\"4331\">\n<p data-start=\"4279\" data-end=\"4331\"><strong data-start=\"4279\" data-end=\"4329\">Alopecia e engrossamento da voz (irrevers\u00edvel)\u00a0 &#8211;\u00a0 em que tem tend\u00eancia\u00a0<\/strong><\/p>\n<\/li>\n<\/ul>\n<h2 data-start=\"4333\" data-end=\"4360\"><span style=\"color: #3366ff;\">Contraindica\u00e7\u00f5es absolutas:<\/span><\/h2>\n<ul data-start=\"4361\" data-end=\"4476\">\n<li data-start=\"4361\" data-end=\"4398\">\n<p data-start=\"4363\" data-end=\"4398\"><strong data-start=\"4363\" data-end=\"4396\">C\u00e2ncer de pr\u00f3stata ou de mama<\/strong><\/p>\n<\/li>\n<li data-start=\"4399\" data-end=\"4433\">\n<p data-start=\"4401\" data-end=\"4433\"><strong data-start=\"4401\" data-end=\"4431\">Apneia do sono n\u00e3o tratada<\/strong><\/p>\n<\/li>\n<li data-start=\"4434\" data-end=\"4476\">\n<p data-start=\"4436\" data-end=\"4476\"><strong data-start=\"4436\" data-end=\"4476\">Insufici\u00eancia card\u00edaca descompensada<\/strong><\/p>\n<\/li>\n<\/ul>\n<hr data-start=\"4478\" data-end=\"4481\" \/>\n<h2 data-start=\"4483\" data-end=\"4509\"><span style=\"color: #3366ff;\"><strong>Monitoramento m\u00e9dico:<\/strong><\/span><\/h2>\n<p data-start=\"4510\" data-end=\"4563\">Durante o tratamento, \u00e9 essencial acompanhamento com:<\/p>\n<ul data-start=\"4564\" data-end=\"4722\">\n<li data-start=\"4564\" data-end=\"4598\">\n<p data-start=\"4566\" data-end=\"4598\"><strong data-start=\"4566\" data-end=\"4596\">Testosterona total e livre\/ Estradiol\/ DHT<\/strong><\/p>\n<\/li>\n<li data-start=\"4599\" data-end=\"4624\">\n<p data-start=\"4601\" data-end=\"4624\"><strong data-start=\"4601\" data-end=\"4622\">PSA e toque retal<\/strong><\/p>\n<\/li>\n<li data-start=\"4625\" data-end=\"4677\">\n<p data-start=\"4627\" data-end=\"4677\"><strong data-start=\"4627\" data-end=\"4675\">Hemograma, fun\u00e7\u00e3o hep\u00e1tica, renal ,\u00a0 coagula\u00e7\u00e3o\u00a0 e perfil lip\u00eddico ( colesterol)<\/strong><\/p>\n<\/li>\n<li data-start=\"4678\" data-end=\"4722\">\n<p data-start=\"4680\" data-end=\"4722\"><strong data-start=\"4680\" data-end=\"4722\">Press\u00e3o arterial e composi\u00e7\u00e3o corporal<\/strong><\/p>\n<\/li>\n<\/ul>\n<p data-start=\"4724\" data-end=\"4838\">Esses par\u00e2metros garantem <strong data-start=\"4750\" data-end=\"4774\">seguran\u00e7a e efic\u00e1cia<\/strong> da reposi\u00e7\u00e3o, prevenindo riscos cardiovasculares e metab\u00f3licos.<\/p>\n<p data-start=\"4724\" data-end=\"4838\">______________________________________________________________________<\/p>\n<\/div>\n<p><strong><span style=\"color: #3366ff;\">Quais os riscos da TRT para a sa\u00fade card\u00edaca?<\/span><\/strong><\/p>\n<ol class=\"mb-3 mt-2 ps-0\">\n<li class=\"Answer-module__MSdfFG__markdownListItem\">\n<p class=\"mb-3 mt-2\"><strong class=\"font-semibold\">M\u00faltiplos estudos n\u00e3o mostraram aumento de risco<\/strong>: V\u00e1rios estudos demonstraram que a TRT n\u00e3o aumenta eventos cardiovasculares ou pode at\u00e9 reduzi-los<\/p>\n<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">\n<p class=\"mb-3 mt-2\"><strong class=\"font-semibold\">Benef\u00edcios em pacientes com insufici\u00eancia card\u00edaca<\/strong>: A TRT mostrou-se segura em pacientes com insufici\u00eancia card\u00edaca classes II-III, melhorando alguns par\u00e2metros card\u00edacos<\/p>\n<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">\n<p class=\"mb-3 mt-2\"><strong class=\"font-semibold\">Meta-an\u00e1lises recentes<\/strong>: An\u00e1lises sistem\u00e1ticas confirmam que a TRT \u00e9 segura quando adequadamente prescrita<\/p>\n<\/li>\n<\/ol>\n<p><em><span style=\"color: #ff0000;\"><strong>A evid\u00eancia atual sugere que os riscos cardiovasculares da TRT podem estar relacionados \u00e0 via de administra\u00e7\u00e3o, dosagem e caracter\u00edsticas do paciente, sendo necess\u00e1ria avalia\u00e7\u00e3o individualizada.<\/strong><\/span><\/em><\/p>\n<div class=\"relative\">\n<div class=\"qa_answer prose-sm max-w-full leading-snug first:*:mt-0 last:*:mb-0 md:text-base md:leading-normal h-xl:text-xl Answer-module__MSdfFG__qaAnswer\">\n<h2 class=\"mb-1 mt-1 text-lg font-medium h-xl:text-2xl\">Riscos Potenciais Identificados<\/h2>\n<ol class=\"mb-3 mt-2 ps-0\">\n<li class=\"Answer-module__MSdfFG__markdownListItem\">\n<p class=\"mb-3 mt-2\"><strong class=\"font-semibold\">Risco aumentado de eventos cardiovasculares maiores<\/strong>: Um estudo canadense mostrou aumento de 27% no risco de eventos cardiovasculares adversos maiores (infarto, revasculariza\u00e7\u00e3o, AVC, insufici\u00eancia card\u00edaca)<\/p>\n<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">\n<p class=\"mb-3 mt-2\"><strong class=\"font-semibold\">Maior risco nos primeiros anos<\/strong>: O risco foi mais elevado nos primeiros 6 meses a 2 anos de uso cont\u00ednuo (35% de aumento) e em homens de 45-59 anos (44% de aumento)<\/p>\n<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">\n<p class=\"mb-3 mt-2\"><strong class=\"font-semibold\">Varia\u00e7\u00e3o por via de administra\u00e7\u00e3o<\/strong>: A TRT oral apresentou risco cardiovascular significativo (RR = 2,20), enquanto as vias intramuscular e transd\u00e9rmica n\u00e3o mostraram risco significativo<\/p>\n<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">\n<p class=\"mb-3 mt-2\"><strong class=\"font-semibold\">Apneia obstrutiva do sono<\/strong>: Risco aumentado de 16,5% em 2 anos versus 12,7% no grupo controle<\/p>\n<\/li>\n<\/ol>\n<p>_________________________________________________________________________<\/p>\n<\/div>\n<\/div>\n<div class=\"streaming-animation markdown prose dark:prose-invert w-full break-words light markdown-new-styling\">\n<h2 data-start=\"542\" data-end=\"596\"><span style=\"color: #0000ff;\"><strong data-start=\"545\" data-end=\"596\">Antes de iniciar a TRT: o que deve ser avaliado<\/strong><\/span><\/h2>\n<p data-start=\"598\" data-end=\"733\"><strong data-start=\"598\" data-end=\"631\">1. Risco cardiovascular geral<\/strong><br data-start=\"631\" data-end=\"634\" \/>O ideal \u00e9 verificar se o paciente tem algum fator que aumente o risco de problemas card\u00edacos, como:<\/p>\n<ul data-start=\"735\" data-end=\"878\">\n<li data-start=\"735\" data-end=\"791\">\n<p data-start=\"737\" data-end=\"791\">hist\u00f3rico de infarto, AVC ou insufici\u00eancia card\u00edaca;<\/p>\n<\/li>\n<li data-start=\"792\" data-end=\"806\">\n<p data-start=\"794\" data-end=\"806\">tabagismo;<\/p>\n<\/li>\n<li data-start=\"807\" data-end=\"820\">\n<p data-start=\"809\" data-end=\"820\">diabetes;<\/p>\n<\/li>\n<li data-start=\"821\" data-end=\"837\">\n<p data-start=\"823\" data-end=\"837\">hipertens\u00e3o;<\/p>\n<\/li>\n<li data-start=\"838\" data-end=\"858\">\n<p data-start=\"840\" data-end=\"858\">colesterol alto;<\/p>\n<\/li>\n<li data-start=\"859\" data-end=\"878\">\n<p data-start=\"861\" data-end=\"878\">idade avan\u00e7ada.<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"880\" data-end=\"1204\">Homens com <strong data-start=\"891\" data-end=\"911\">disfun\u00e7\u00e3o er\u00e9til<\/strong> tamb\u00e9m merecem uma investiga\u00e7\u00e3o mais cuidadosa, j\u00e1 que muitas vezes ela \u00e9 um marcador precoce de doen\u00e7a cardiovascular. Nesses casos, exames como <strong data-start=\"1058\" data-end=\"1087\">perfil lip\u00eddico, glicemia<\/strong> e, para quem tem maior risco ou sintomas, <strong data-start=\"1130\" data-end=\"1151\">teste ergom\u00e9trico<\/strong> ou <strong data-start=\"1155\" data-end=\"1183\">tomografia de coron\u00e1rias<\/strong> podem ser indicados.<\/p>\n<p data-start=\"1206\" data-end=\"1297\"><strong data-start=\"1206\" data-end=\"1241\">2. Exames iniciais obrigat\u00f3rios<\/strong><br data-start=\"1241\" data-end=\"1244\" \/>Antes de come\u00e7ar a testosterona, devem ser avaliados:<\/p>\n<ul data-start=\"1299\" data-end=\"1530\">\n<li data-start=\"1299\" data-end=\"1346\">\n<p data-start=\"1301\" data-end=\"1346\">hemograma (com aten\u00e7\u00e3o ao <strong data-start=\"1327\" data-end=\"1342\">hemat\u00f3crito<\/strong>);<\/p>\n<\/li>\n<li data-start=\"1347\" data-end=\"1379\">\n<p data-start=\"1349\" data-end=\"1379\">colesterol e triglicer\u00eddeos;<\/p>\n<\/li>\n<li data-start=\"1380\" data-end=\"1415\">\n<p data-start=\"1382\" data-end=\"1415\">glicemia e hemoglobina glicada;<\/p>\n<\/li>\n<li data-start=\"1416\" data-end=\"1442\">\n<p data-start=\"1418\" data-end=\"1442\">press\u00e3o arterial, IMC;<\/p>\n<\/li>\n<li data-start=\"1443\" data-end=\"1501\">\n<p data-start=\"1445\" data-end=\"1501\">PSA e toque retal conforme idade e hist\u00f3rico familiar;<\/p>\n<\/li>\n<li data-start=\"1502\" data-end=\"1530\">\n<p data-start=\"1504\" data-end=\"1530\">triagem de apneia do sono.<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1532\" data-end=\"1609\">Registrar o hemat\u00f3crito <strong data-start=\"1556\" data-end=\"1565\">antes<\/strong> da TRT \u00e9 importante para compara\u00e7\u00e3o futura.<\/p>\n<p data-start=\"1611\" data-end=\"1678\"><strong data-start=\"1611\" data-end=\"1639\">3. Quando evitar iniciar<\/strong><\/p>\n<p data-start=\"1611\" data-end=\"1678\"><br data-start=\"1639\" data-end=\"1642\" \/><strong><span style=\"color: #ff6600;\">A TRT deve ser adiada em casos como:<\/span><\/strong><\/p>\n<ul data-start=\"1680\" data-end=\"1767\">\n<li data-start=\"1680\" data-end=\"1719\">\n<p data-start=\"1682\" data-end=\"1719\">infarto ou AVC nos \u00faltimos 6 meses;<\/p>\n<\/li>\n<li data-start=\"1720\" data-end=\"1767\">\n<p data-start=\"1722\" data-end=\"1767\">insufici\u00eancia card\u00edaca grave e descompensada.<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1769\" data-end=\"1903\">Em situa\u00e7\u00f5es mais complexas, a decis\u00e3o deve ser discutida individualmente, j\u00e1 que a literatura cient\u00edfica ainda tem resultados mistos.<\/p>\n<hr data-start=\"1905\" data-end=\"1908\" \/>\n<h2 data-start=\"1910\" data-end=\"1975\"><span style=\"color: #0000ff;\"><strong data-start=\"1913\" data-end=\"1975\">Monitoriza\u00e7\u00e3o durante a TRT: o que precisa ser acompanhado<\/strong><\/span><\/h2>\n<p data-start=\"1977\" data-end=\"2003\"><strong data-start=\"1977\" data-end=\"2001\">1. Hemat\u00f3crito (Hct)<\/strong><\/p>\n<ul data-start=\"2004\" data-end=\"2270\">\n<li data-start=\"2004\" data-end=\"2087\">\n<p data-start=\"2006\" data-end=\"2087\">Repetir em <strong data-start=\"2017\" data-end=\"2028\">3 meses<\/strong>, depois em <strong data-start=\"2040\" data-end=\"2051\">6 meses<\/strong> e, se est\u00e1vel, a cada 6\u201312 meses.<\/p>\n<\/li>\n<li data-start=\"2088\" data-end=\"2159\">\n<p data-start=\"2090\" data-end=\"2159\">Um Hemet\u00f3crito muito elevado aumenta o risco de eventos como infarto e AVC.<\/p>\n<\/li>\n<li data-start=\"2160\" data-end=\"2270\">\n<p data-start=\"2162\" data-end=\"2270\">Se atingir <strong data-start=\"2173\" data-end=\"2188\">54% ou mais<\/strong>, deve-se <strong data-start=\"2198\" data-end=\"2214\">reduzir dose<\/strong>, <strong data-start=\"2216\" data-end=\"2249\">trocar a via de administra\u00e7\u00e3o<\/strong> ou <strong data-start=\"2253\" data-end=\"2263\">pausar<\/strong> a TRT.<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"2272\" data-end=\"2511\"><strong data-start=\"2272\" data-end=\"2313\">2. Sintomas e sinais cardiovasculares: <\/strong>O paciente deve ser reavaliado quanto \u00e0 capacidade de esfor\u00e7o, dor no peito e falta de ar.<br data-start=\"2406\" data-end=\"2409\" \/>Embora muitos estudos mostrem <strong data-start=\"2439\" data-end=\"2471\">boa seguran\u00e7a cardiovascular<\/strong>, o acompanhamento cont\u00ednuo \u00e9 essencial.<\/p>\n<p data-start=\"2513\" data-end=\"2614\"><strong data-start=\"2513\" data-end=\"2545\">3. Apneia obstrutiva do sono<\/strong><br data-start=\"2545\" data-end=\"2548\" \/>A TRT pode aumentar a chance de desenvolver ou agravar a apneia.<\/p>\n<ul data-start=\"2615\" data-end=\"2814\">\n<li data-start=\"2615\" data-end=\"2697\">\n<p data-start=\"2617\" data-end=\"2697\">Em dois anos, o risco observado foi de <strong data-start=\"2656\" data-end=\"2674\">16,5% vs 12,7%<\/strong> em quem n\u00e3o usa TRT.<\/p>\n<\/li>\n<li data-start=\"2698\" data-end=\"2814\">\n<p data-start=\"2700\" data-end=\"2814\">Se houver ronco intenso, pausas respirat\u00f3rias ou sonol\u00eancia exagerada, deve-se investigar com <strong data-start=\"2794\" data-end=\"2813\">polissonografia<\/strong>.<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"2816\" data-end=\"3057\"><strong data-start=\"2816\" data-end=\"2865\">4. Metabolismo, colesterol e press\u00e3o arterial<\/strong><br data-start=\"2865\" data-end=\"2868\" \/>Todos os demais fatores de risco cardiovascular devem ser controlados conforme as diretrizes de preven\u00e7\u00e3o : tratamento de hipertens\u00e3o, diabetes, dislipidemia e otimiza\u00e7\u00e3o do estilo de vida.<\/p>\n<p data-start=\"2816\" data-end=\"3057\">______________________________________________________________________________<\/p>\n<h2 data-start=\"5207\" data-end=\"5222\"><span style=\"color: #3366ff;\"> Conclus\u00e3o:<\/span><\/h2>\n<p data-start=\"5223\" data-end=\"5531\">A testosterona exerce <strong data-start=\"5245\" data-end=\"5314\">influ\u00eancia direta e positiva sobre o cora\u00e7\u00e3o, vasos e metabolismo<\/strong>, desde que mantida dentro dos <strong data-start=\"5345\" data-end=\"5368\">n\u00edveis fisiol\u00f3gicos<\/strong>.<\/p>\n<p data-start=\"5223\" data-end=\"5531\"><br data-start=\"5369\" data-end=\"5372\" \/>A reposi\u00e7\u00e3o, quando indicada corretamente e acompanhada de perto por um m\u00e9dico, <strong data-start=\"5452\" data-end=\"5530\">pode melhorar o perfil lip\u00eddico, o desempenho card\u00edaco e o bem-estar geral<\/strong>.<\/p>\n<p><span style=\"color: #ff6600;\">&#8220;Por outro lado, o <strong data-start=\"5551\" data-end=\"5595\">uso abusivo ou sem acompanhamento m\u00e9dico<\/strong> pode causar o efeito oposto, aumentando o risco de trombose, arritmias e eventos cardiovasculares&#8221;<\/span>_______________________________________________________________________<\/p>\n<div class=\"flex w-full items-center justify-between gap-1 px-5 pb-2.5 text-xl font-medium md:text-2xl h-xl:text-3xl\">\n<h2 class=\"relative grow overflow-hidden text-ellipsis\"><span style=\"color: #0000ff;\">Como a testosterona afeta a sa\u00fade cardiovascular em homens mais velhos?<\/span><\/h2>\n<\/div>\n<div class=\"relative\">\n<div class=\"qa_answer prose-sm max-w-full leading-snug first:*:mt-0 last:*:mb-0 md:text-base md:leading-normal h-xl:text-xl Answer-module__MSdfFG__qaAnswer\">\n<p class=\"mb-3 mt-2\">A testosterona tem efeitos complexos na sa\u00fade cardiovascular de homens mais velhos, com evid\u00eancias mostrando tanto associa\u00e7\u00f5es protetoras quanto riscos potenciais.<\/p>\n<p><span style=\"color: #ff6600;\">N\u00edveis End\u00f3genos de Testosterona:<\/span><\/p>\n<ol class=\"mb-3 mt-2 ps-0\">\n<li class=\"Answer-module__MSdfFG__markdownListItem\">\n<p class=\"mb-3 mt-2\"><strong class=\"font-semibold\">Associa\u00e7\u00f5es com mortalidade<\/strong>: N\u00edveis baixos de testosterona end\u00f3gena est\u00e3o associados a maior mortalidade cardiovascular, com riscos aumentando abaixo de 5,3 nmol\/L (153 ng\/dL)\u00a0<span class=\"text-nowrap\" data-state=\"closed\"><span class=\"mx-1 inline-grid shrink-0 cursor-pointer place-items-center rounded-full text-mediblue-base size-4 -translate-y-1 border border-mediblue-light-4 bg-mediblue-light-6 text-center text-[10px] font-bold leading-[10px] h-xl:size-5 h-xl:text-[12px] h-xl:leading-[12px]\"><span class=\"sr-only\">[1]<\/span>1<\/span><\/span><\/p>\n<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">\n<p class=\"mb-3 mt-2\"><strong class=\"font-semibold\">Eventos cardiovasculares<\/strong>: Estudos prospectivos mostram que testosterona mais baixa prediz consistentemente maior incid\u00eancia de eventos cardiovasculares, especialmente AVC\u00a0<span class=\"text-nowrap\" data-state=\"closed\"><span class=\"mx-1 inline-grid shrink-0 cursor-pointer place-items-center rounded-full text-mediblue-base size-4 -translate-y-1 border border-mediblue-light-4 bg-mediblue-light-6 text-center text-[10px] font-bold leading-[10px] h-xl:size-5 h-xl:text-[12px] h-xl:leading-[12px]\"><span class=\"sr-only\">[2]<\/span>2<\/span><\/span><\/p>\n<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">\n<p class=\"mb-3 mt-2\"><strong class=\"font-semibold\">Insufici\u00eancia card\u00edaca<\/strong>: N\u00edveis altos de testosterona s\u00e9rica associam-se a menor risco de insufici\u00eancia card\u00edaca congestiva (OR: 0,47; IC 95%: 0,27-0,80)<\/p>\n<\/li>\n<\/ol>\n<p><span style=\"color: #ff6600;\">Terapia de Reposi\u00e7\u00e3o de Testosterona<\/span><\/p>\n<ol class=\"mb-3 mt-2 ps-0\">\n<li class=\"Answer-module__MSdfFG__markdownListItem\">\n<p class=\"mb-3 mt-2\"><strong class=\"font-semibold\">Seguran\u00e7a cardiovascular<\/strong>: O estudo TRAVERSE n\u00e3o encontrou aumento no risco de eventos cardiovasculares adversos maiores com tratamento de testosterona<\/p>\n<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">\n<p class=\"mb-3 mt-2\"><strong class=\"font-semibold\">Riscos espec\u00edficos<\/strong>:<\/p>\n<ul class=\"mb-3 mt-2 ps-0\">\n<li class=\"Answer-module__MSdfFG__markdownListItem\">Fibrila\u00e7\u00e3o atrial: Homens com testosterona nos quintis mais altos t\u00eam risco 91-98% maior de fibrila\u00e7\u00e3o atrial<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">Progress\u00e3o de placa: Tratamento aumentou volume de placa n\u00e3o calcificada coronariana em 41 mm\u00b3<\/li>\n<\/ul>\n<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">\n<p class=\"mb-3 mt-2\"><strong class=\"font-semibold\">Efeitos metab\u00f3licos<\/strong>: Redu\u00e7\u00e3o modesta no colesterol total (-6,1 mg\/dL) e insulina (-1,7 \u00b5IU\/mL)<\/p>\n<\/li>\n<\/ol>\n<p class=\"mb-3 mt-2\">A testosterona pode influenciar humor, energia e cogni\u00e7\u00e3o em homens, mas os efeitos variam conforme n\u00edveis hormonais e presen\u00e7a de hipogonadismo. Em geral, os benef\u00edcios sobre sintomas depressivos s\u00e3o modestos.<\/p>\n<p>________________________________________________________<\/p>\n<h2 class=\"relative grow overflow-hidden text-ellipsis\"><span style=\"color: #0000ff;\">Como a testosterona afeta a sa\u00fade mental em homens?<\/span><\/h2>\n<p class=\"mb-3 mt-2\"><span style=\"color: #ff6600;\"><strong class=\"font-semibold\">Depress\u00e3o e humor<\/strong><\/span><\/p>\n<ul class=\"mb-3 mt-2 ps-0\">\n<li class=\"Answer-module__MSdfFG__markdownListItem\">Em meta\u2011an\u00e1lise de 27 ensaios (n=1890), terapia com testosterona reduziu sintomas depressivos com tamanho de efeito pequeno e dobrou a chance de resposta cl\u00ednica em compara\u00e7\u00e3o ao placebo<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">Revis\u00f5es mostram melhora sobretudo em homens hipogonadais e com depress\u00e3o leve\/sub\u2011limiar; o efeito \u00e9 inconsistente em depress\u00e3o maior<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">Em hipogonadismo, ensaio recente observou melhora pequena por\u00e9m significativa em humor e energia; n\u00e3o houve ganho em sono ou cogni\u00e7\u00e3o<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">Rede de meta\u2011an\u00e1lises indica redu\u00e7\u00e3o de escores de depress\u00e3o como classe terap\u00eautica, com magnitude pequena (<\/li>\n<\/ul>\n<p class=\"mb-3 mt-2\"><span style=\"color: #ff6600;\"><strong class=\"font-semibold\">Cogni\u00e7\u00e3o e outros desfechos<\/strong><\/span><\/p>\n<ul class=\"mb-3 mt-2 ps-0\">\n<li class=\"Answer-module__MSdfFG__markdownListItem\">Em homens eugonadais (testosterona normal), suplementa\u00e7\u00e3o n\u00e3o melhorou globalmente cogni\u00e7\u00e3o; efeito global foi nulo a muito pequeno e n\u00e3o clinicamente relevante<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">Caracter\u00edsticas de ensaios n\u00e3o explicaram varia\u00e7\u00f5es de efeito, sugerindo resultados est\u00e1veis mas modestos<\/li>\n<\/ul>\n<p class=\"mb-3 mt-2\"><strong>Em s\u00edntese, a testosterona pode melhorar levemente humor\/energia, principalmente em homens com n\u00edveis baixos confirmados; a evid\u00eancia n\u00e3o apoia benef\u00edcios cognitivos relevantes e \u00e9 limitada para depress\u00e3o maior<\/strong><\/p>\n<p>____________________________________________________________<\/p>\n<\/div>\n<\/div>\n<\/div>\n<h2 class=\"relative grow overflow-hidden text-ellipsis\"><span style=\"color: #0000ff;\">A testosterona \u00e9 recomendada para tratar depress\u00e3o maior?<\/span><\/h2>\n<p class=\"mb-3 mt-2\">A recomenda\u00e7\u00e3o padr\u00e3o para depress\u00e3o maior (TDM) continua sendo antidepressivos e psicoterapia; a testosterona n\u00e3o \u00e9 tratamento de primeira linha e seu uso \u00e9, no m\u00e1ximo, adjunto em casos selecionados.<\/p>\n<p class=\"mb-3 mt-2\"><span style=\"color: #ff6600;\"><strong class=\"font-semibold\">O que mostram as evid\u00eancias:<\/strong><\/span><\/p>\n<ul class=\"mb-3 mt-2 ps-0\">\n<li class=\"Answer-module__MSdfFG__markdownListItem\">Meta\u2011an\u00e1lises de ensaios randomizados indicam redu\u00e7\u00e3o pequena de sintomas depressivos com testosterona\u00a0 mas com heterogeneidade e sem foco espec\u00edfico em TDM como desfecho prim\u00e1rio<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">Revis\u00e3o em homens com defici\u00eancia tardia de testosterona sugere melhora em depress\u00e3o leve\/sub\u2011limiar, mas n\u00e3o demonstra benef\u00edcio consistente em depress\u00e3o maior diagnosticada<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">An\u00e1lises mais antigas mostram efeitos maiores em hipogonadais e em depress\u00e3o sub\u2011limiar; como augmenta\u00e7\u00e3o em TDM \u00e9 considerada potencial e experimental, n\u00e3o estabelecida<\/li>\n<li class=\"Answer-module__MSdfFG__markdownListItem\">Estudos metodol\u00f3gicos n\u00e3o identificam caracter\u00edsticas de ensaios que expliquem varia\u00e7\u00f5es de efeito, refor\u00e7ando incerteza e necessidade de RCTs focados em TDM<\/li>\n<\/ul>\n<p class=\"mb-3 mt-2\">Em s\u00edntese, a testosterona n\u00e3o \u00e9 recomendada como monoterapia para TDM; pode ser considerada como adjuvante apenas em homens com hipogonadismo confirmado e resposta parcial a tratamento padr\u00e3o, com expectativa de benef\u00edcio modesto e monitoriza\u00e7\u00e3o rigorosa<\/p>\n<div class=\"streaming-animation markdown prose dark:prose-invert w-full break-words light markdown-new-styling\">\n<div class=\"relative\">\n<div class=\"qa_answer prose-sm max-w-full leading-snug first:*:mt-0 last:*:mb-0 md:text-base md:leading-normal h-xl:text-xl Answer-module__MSdfFG__qaAnswer\">\n<h2 id=\"radix-_r_2n_\" class=\"tracking-tight text-2xl font-medium @xs:text-3xl\"><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<p>_______________________________________________________<\/p>\n<\/div>\n<\/div>\n<h2 class=\"h5\">Refer\u00eancias :<\/h2>\n<div class=\"row\">\n<div class=\"col ref-list\">\n<ul class=\"refList articleFootnotes\">\n<li data-start=\"616\" data-end=\"812\">\n<p data-start=\"619\" data-end=\"812\"><strong data-start=\"619\" data-end=\"667\">MORALES, A.; HEATON, J. 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G. <em data-start=\"1172\" data-end=\"1180\">et al.<\/em> Endogenous testosterone, testosterone treatment, and cardiovascular health outcomes in men. <strong data-start=\"1273\" data-end=\"1327\">The Journal of Clinical Endocrinology &amp; Metabolism<\/strong>, Oxford, 2024. Dispon\u00edvel em: <a class=\"decorated-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41223023\/\" target=\"_new\" rel=\"noopener\" data-start=\"1358\" data-end=\"1401\">https:\/\/pubmed.ncbi.nlm.nih.gov\/41223023\/<\/a><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>____________________________________ Com o envelhecimento h\u00e1 um incremento na preval\u00eancia de doen\u00e7as cardiovasculares \u00a0Paralelamente, ocorre redu\u00e7\u00e3o progressiva na concentra\u00e7\u00e3o\u00a0 dos horm\u00f4nios sexuais masculinos, sendo que nas faixas et\u00e1rias mais avan\u00e7adas a testosterona \u00e9 reduzida em, aproximadamente, 15 a 20% \u00a0dos indiv\u00edduos. Os receptores de testosterona\u00a0 distribuem-se amplamente nos tecidos vasculares, como art\u00e9ria aorta vasculatura perif\u00e9rica c\u00e9lulas [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":12032,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[36,652],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Efeitos da Testosterona no Cora\u00e7\u00e3o e na Sa\u00fade Mental. - Dr. Roberto Franco do Amaral Neto<\/title>\n<meta name=\"description\" content=\"N\u00edveis adequados de testosterona podem melhorar a fun\u00e7\u00e3o card\u00edaca e 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